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Food for thought about the immune drivers of gut pain – Nature.com

Defence against bacterial infection can drive pain when eating food.

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Pain evolved to alert us to and protect us from actual or potential tissue damage. There are three common forms: nociceptive pain, which is associated with the detection of damaging stimuli; inflammatory pain, associated with inflammation or infection; and chronic pain, which is a maladaptive, long-term form of pain1. Writing in Nature, Aguilera-Lizarraga et al.2 report evidence from mice and humans indicating a previously unknown mechanism that contributes to chronic gut pain.
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